A preliminary study to investigate the efficacy of urinary syndecan-1 as a marker of glycocalyx collapsing and subsequential vascular endothelial infringement in patients with sepsis (PIE US-1M VIPS)
敗血症患者の尿中シンデカン-1と血管内皮障害の関係を調べる予備的研究
Preliminay study of urinary syndecan- 1 measurement to investigate association with onset of vascular- endothelial injury in patients with sepsis (US-1 MIAO VIPS/ MIAO)
(2)研究責任医師(多施設共同研究の場合は、研究代表医師)に関する事項等
田澤 和雅
Tazawa Kazumasa
/
埼玉医科大学総合医療センター
Department of Anesthesiology, Saitama Medical Center, Saitama Medical University
麻酔科
350-0844
/
埼玉県川越市鴨田1981 本館4階
4th floor, 1981 Kamoda, Kawagoe, Saitama, Japan
0492283654
wacchi7@gmail.com
田澤 和雅
Kazumasa Tazawa
埼玉医科大学総合医療センター
Saitama Medical Center, Saitama Medical University
麻酔科
350-0844
埼玉県川越市鴨田1981 本館4階
4F 1981 Kamoda, Kawagoe, Saitama, Japan
0492283654
0492262237
wacchi7@gmail.com
田澤 和雅
あり
令和5年2月2日
集中治療室(GICU)
(3)研究責任医師以外の臨床研究に従事する者に関する事項
鈴木 俊成
Suzuki Toshinari
90337600
埼玉医科大学総合医療センター 麻酔科
Department of Anestheology, Saitama Medical Center, Saitama Medical University
准教授
該当
伊野田 絢子
Inoda Ayako
埼玉医科大学総合医療センター 麻酔科
Department of Anesthesiology, Saitama Medical Center, Saitama Medical University
助教
非該当
仕子 優樹
Shiko Yuki
埼玉医科大学総合医療センター 麻酔科
Department of Anesthesiology, Saitama Medical Center, Saitama Medical University
客員准教授 研究員
非該当
川崎 洋平
Kawasaki Yohei
埼玉医科大学総合医療センター 麻酔科
Department of Anesthesiology, Saitama Medical Center, Saitama Medical University
客員准教授 研究員
非該当
小山 薫
Koyama Kaoru
埼玉医科大学総合医療センター 麻酔科
Department of Anesthesiology, Saitama Medical Center, Saitama Medical University
Sepsis and septic shock patients who need crinical care at general intensive care unit ( GICU) in our institution.
Define of sepsis: Infection diagnoted or suspected, with organ dysfunction with acute elevation of SOFA score over two points.
Define of septic shock: Sepsis with high blood lactate acid above 2 mmol/L (18 mg/dL), and need vasocontractive drug in addition to fluid resuscitation to keep mean arterial blood bressure over 65 mmHg.
Patients who are not gotten concented, not available to insert cathetel into bladder, not available to take urea, emergent and obvious critical life- threatning situation, and have any possiblity to effect this study.
Comparison of both blood and urinary syndecan -1 at 4 time points below
start of staying GICU, 1 day after start of treatment, 2 day after start of treatment, end of staying GICU
Compare trend of both blood and urinary syndecan- 1, 30 days mortality etc in two groups which allocated to severe group and non- severe group with SOFA score of entering into GICU.